Presenter: Dr. Manuel F. LΓ³pez Aranda (University of MΓ‘laga, Spain)
Presentation Type: Oral Presentation (Virtual)
Title: Severe postnatal infections increase autism risk in genetically predisposed males: Mechanistic and therapeutic implications
π¬ Presentation Highlights
∙ Focus: How early-life immune activation interacts with genetic vulnerability to increase autism spectrum disorder (ASD) risk.
∙ Genetic Context: Tuberous Sclerosis Complex (TSC) — a disorder with 40–60% ASD prevalence compared to 1–2% in the general population.
∙ Key Finding (Preclinical Model): Early postnatal immune challenges caused profound social memory deficits and atypical communication specifically in male Tsc2+/- mice.
∙ Mechanism Identified: Dysregulated mTOR-dependent interferon signaling and microglial dysfunction drive sex-specific neurodevelopmental changes.
∙ Therapeutic Breakthrough: Rapamycin treatment both prevented and durably reversed social deficits in genetically vulnerable males.
∙ Genetic Protection: Deletion of interferon receptor IFNAR1 protected against immune-induced behavioral impairments.
∙ Human Data Validation: Analysis of 3+ million medical records revealed that severe early-life infections requiring hospitalization significantly increased ASD risk in boys, but not girls.
∙ Clinical Implications: Highlights potential therapeutic strategies targeting mTOR and interferon pathways in neurodevelopmental and neuropsychiatric disorders.
π¨π¬ About the Speaker
Dr. Manuel F. LΓ³pez Aranda, Ph.D., is a Distinguished Researcher at the University of MΓ‘laga (Spain) under the Beatriz Galindo Program.
∙ Ph.D. in Neuroscience, University of MΓ‘laga
∙ Postdoctoral Training at UCLA; served as Assistant Project Scientist
∙ Research Expertise: Neurobiology of learning & memory, microglia, immune activation in ASD and Alzheimer’s disease
∙ Published in leading journals including Science, Nature Reviews Neuroscience, and Science Advances
∙ Internationally recognized for translational research bridging genetics, immunology, and neurodevelopment
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